A systematic review of antibody mediated immunity to coronaviruses

The duration and nature of immunity generated in response to SARS-CoV-2 infection is unknown. Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The timescale of protection is a critical determinant of the future impact of the pathogen. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. The dynamics of immunity and nature of protection are relevant to discussions surrounding therapeutic use of convalescent sera as well as efforts to identify individuals with protective immunity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV-1, MERS-CoV and human endemic coronaviruses (HCoVs). We reviewed 1281 abstracts and identified 322 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While studies of SARS-CoV-2 are necessary to determine immune responses to it, evidence from other coronaviruses can provide clues and guide future research.

Fig :Aspects of antibody response included in this review. This figure shows the areas of focus of our review within our conceptualisation of the stages of exposure and infection at which we believe antibody mediated immunity may play a role in the dynamics of SARS-CoV-2. At the individual level (left), antibody response following the first infection/exposure increases and then declines (Antibody kinetics). Sometime later individuals may be exposed to SARS-CoV-2 again. They may be protected from infection by their acquired immunity (Correlates of protection). Their acquired immunity may also moderate the severity of infection with some possibility that pre-existing immunity may lead to immunopathogenesis (relevant to both first and second exposure). These individual-level dynamics aggregate to form the population-level seroprevalence (right-top). Measures of seroprevalence may imperfectly measure past exposure to infection due to antigenic diversityof future SARS-CoV-2 viruses and cross-reactivity of endemic human coronaviruses (HCoVs) with SARS-CoV-2. Measures of seroprevalence may also be inconsistent across times as antibodies-levels within individuals wane

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