Several independent research groups have identified that SARS-CoV-2 belongs toβ-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor,angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe.The clinical symptoms of COVID-19 patients include fever,cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and proneto serious outcomes, which may be associated with acute respiratory distress syndrome(ARDS) and cytokine storm.Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs areunder urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis,and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.
Ref And Source of Information Guoet al. Military Medical Research (2020) 7:11 https://doi.org/10.1186/s40779-020-00240-